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KMID : 1009020220200020228
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Clinical Psychopharmacology and Neuroscience
2022 Volume.20 No. 2 p.228 ~ p.239
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Neuromolecular Etiology of Bipolar Disorder: Possible Therapeutic Targets of Mood Stabilizers
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Lee Jung-Goo
Woo Young-Sup
Park Sung-Woo
Seog Dae-Hyun
Seo Mi-Kyoung
Bahk Won-Myong
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Abstract
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Bipolar disorder is a mental illness that causes extreme mood swings and has a chronic course. However, the mechanism by which mood episodes with completely opposite characteristics appear repeatedly, or a mixture of symptoms appears, in patients with bipolar disorder remains unknown. Therefore, mood stabilizers are indicated only for single mood episodes, such as manic episodes and depressive episodes, and no true mood-stabilizing drugs effective for treating both manic and depressive episodes currently exist. Therefore, in this review, therapeutic targets that facilitate the development of mood stabilizers were examined by reviewing the current understanding of the neuromolecular etiology of bipolar disorder.
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KEYWORD
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Bipolar disorder, Drug therapy, Neurobiology
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